![]() ![]() ![]() Her dyspnea has been ascribed to sedentary lifestyle and severe anemia in the context of multiple myeloma. Of note, arterial blood gases are influenced not only by the integrity of the alveolar-capillary membrane but also by hemodynamic factors (e.g., poor peripheral tissue perfusion leading to low mixed venous O2 pressure) and changes in ventilatory drive (e.g., hypoventilation leading to hypercapnia and hypoxemia) among others.(1) Due to the ominous systemic consequences of impaired pulmonary gas exchange, tests addressing its multifaceted features are germane to the practice of Pulmonology.Ī 71-year-old current smoker woman was referred to the pulmonology clinic due to progressing exertional dyspnea (modified Medical Research Council score = 3/4) despite normal spirometry, lung volumes, and contrast-enhanced chest CT results. Most of the pulmonary function tests, however, explore potential abnormalities in a step that precedes alveolar gas exchange, i.e., ventilation (VE). The lungs are the organs responsible for maintaining an adequate PaCO2 for the level of CO2 production (VCO2) while avoiding critical decrements in PaO2. The human body is primarily concerned with the stability of pH. ![]()
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